Composition
Each Alfaflavox film coated tablet contains flavoxate hydrochloride 200 mg.
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Indications
Alfaflavox is indicated for the symptomatic relief of
dysuria, urgency, octuria, vesical supra-pubic pain,
frequency and incontinence as may occur in cystitis,
prostatitis, urethritis, urethro-cystitis and urethrotrigonitis.
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Dosage
Adults (including the elderly):
The recommended adult dosage is one tablet three times a day for as long as required.
Children:
Alfaflavox tablets are not recommended for children under 12 years of age.
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How Supplied
Carton box containing 1, 2 or 3 (Al/transparent PVC)
strips, each of 10 film coated tablets and an inner leaflet.
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Clinical Pharmacology
Flavoxate hydrochloride (and its main metabolite methyl flavone carboxylic acid, MFCA) is an antispasmodic selective to the urinary tract. In animal and human studies,
flavoxate hydrochloride has been shown to have a direct antispasmodic action on smooth muscle fibres.
The mechanism of action involves intracellular cyclic AMP accumulation and calcium blocking activity. It inhibits bladder contractions induced by various agonists or by electrical stimulation and inhibits the frequency of bladder voiding contractions.
It increases bladder volume capacity, reduces the threshold and micturition pressure.
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