Composition
Mirtazapine 30 mg.
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Indications
Treatment of major depression.
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Dosage
One tablet once daily.
(The effective daily dose is usually between
15 and 45 mg)
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How Supplied
Box of 1, 2, 3, 5 or 10 strips, each strip of
10 tablets.
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Mechanism of action
Mirtazapine is a centrally active presynaptic ALFA 2-antagonist, which increases central noradrenergic and serotonergic neurotransmission. The enhancement of serotonergic neurotransmission is specifically mediated via 5-HT1 receptors, because 5-HT2 and
5-HT3 receptors are blocked by mirtazapine.
The clearance of mirtazapine may be decreased in patients with moderate to severe
renal impairment.
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Special Populations
Elderly:
The recommended dose is the same as that for adults.
Children and Adolescents:
Mirtadepine should not be used in children and adolescents as efficacy was not demonstrated in two short-term clinical trials, and because of safety concerns.
Renal impaired patients:
The clearance of mirtazapine may be decreased in patients with moderate to severe renal impairment.
Liver impaired patients:
The clearance of mirtazapine may be decreased in patients with hepatic impairment.
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