Composition
Each 1ml Nalpain® Ampoule Contains:
Nalbuphine Hydrochloride 20 mg / 1 ml.
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Indications
Nalpain® is indicated for the relief of moderate to
severe pain.
For preoperative and postoperative analgesia, and for obstetrical analgesia during labor and delivery.
Nalpain® can also be used as a supplement to
balanced anesthesia.
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Dosage
The usual recommended adult dose is 10 mg for a 70 kg individual, administered
subcutaneously, intramuscularly or intravenously; this dose may be repeated every 3 to 6 hours as necessary. (1 Ampoule up to 8 times daily)
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How Supplied
Carton box containing 1, 5, or 10 ampoules, each of 1 ml.
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Clinical Pharmacology
Nalpain® is a potent analgesic. Its analgesic potency is essentially equivalent to that of morphine on a milligram basis.
Receptor studies show that Nalpain® binds to mu, kappa, and delta receptors, but not to sigma receptors. Nalpain® is primarily a kappa agonist/partial mu antagonist analgesic.
The onset of action of Nalpain® occurs within 2 to 3 minutes after intravenous administration, and in less than 15 minutes following subcutaneous or intramuscular injection.
The plasma half-life of nalbuphine is 5 hours, and in clinical studies the duration of analgesic activity has been reported to range from 3 to 6 hours.
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