Composition
Each 1 ml solution contains:
trimethoprim 1mg.
polymyxin B sulphate (Micronized) 10000 units.
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Indications
Polaprim Ophthalmic Solution is indicated in the treatment of surface ocular bacterial infections, including acute bacterial conjunctivitis, and blepharoconjunctivitis, caused by susceptible strains.
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Dosage
In mild to moderate infections, instill one drop in the affected eye(s) every three hours (maximum of 6 doses per day) for a period of 7 to 10 days.
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How Supplied
Carton box containing plastic dropper bottle of 10 ml.
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Mechanism of action
Trimethoprim blocks the production of tetrahydrofolic acid from dihydrofolic acid by binding to and reversibly inhibiting the enzyme dihydrofolate reductase. This binding is stronger for the bacterial enzyme than for the corresponding mammalian enzyme and
therefore selectively interferes with bacterial biosynthesis of nucleic acids and proteins.
Polymyxin B increases the permeability of the bacterial cell membrane by interacting with the phospholipid components of the membrane.
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Special Populations
Pregnancy: Pregnancy Category C.
Nursing Mothers: It is not known whether this drug is excreted in human milk.
Pediatric Use: Safety and effectiveness in children below the age of 2 months have not been established.
Geriatric Use: No overall differences in safety or effectiveness have been observed between elderly and other adult patients.
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